Harvard University txoj kev tshawb nrhiav pom Benzyl Butyl Phthalate (BBP) puas DNA thiab ua rau cov kab mob germline Dysfunction
Cov kws tshawb fawb los ntawm Tsev Kawm Ntawv Kho Mob Harvard tau tshaj tawm txoj kev tshawb fawb hauvPLOS Geneticsnthuav tawm tias cov yas siv feem ntau, benzyl butyl phthalate (BBP), tuaj yeem ua rau DNA puas thiab ua rau tsis ua haujlwm hauv cov kab mob.
Thaum Lub Kaum Hli 24, 2024, cov kws tshawb fawb los ntawm Harvard Medical School tau luam tawm ib daim ntawv hu uaKev cuam tshuam rau Benzyl Butyl Phthalate (BBP) ua rau muaj kev nce ntxiv ntawm ob-strand tawg tsim thiab germline tsis ua haujlwm hauvCaenorhabditis elegans* hauvPLOS Genetics. Txoj kev tshawb fawb tshiab no qhia txog qhov muaj peev xwm ua rau BBP tuaj yeem ua rau lub cev xeeb tub.
Pab neeg tshawb fawb tau sim ntau yam tshuaj BBP ntawmCaenorhabditis elegans(C. elegans), tus qauv kab mob, thiab pom tias 10μM koob tshuaj BBP muaj qhov cuam tshuam loj tshaj plaws ntawm cov kab mob. Qhov kev tshwm sim no ua rau muaj kev nce apoptosis ntawm cov kab mob ntawm cov kab mob thiab cov teeb meem hauv lub koom haum chromosome. Tshwj xeeb, BBP ua rau oxidative kev nyuaj siab thiab DNA ob-strand so, ua rau cell tuag thiab oocytes nrog chromosomal txawv txav.
Mass spectrometry tsom xam pom tau tiasC. eleganstuaj yeem metabolize BBP rau hauv mono-butyl phthalate (MBP) thiab mono-benzyl phthalate (MBzP). Cov qib ntawm BBP, MBP, thiab MBzP kuaj pom hauvC. eleganstau zoo ib yam li qhov muaj nyob hauv tib neeg cov qauv lom neeg, xws li ntshav thiab zis. Qhov no qhia tiasC. elegansyog ib qho qauv zoo rau kev kawm txog cov teebmeem ntawm BBP rau tib neeg kev noj qab haus huv.
Txoj kev tshawb no qhia txog cov teebmeem tshuaj lom ntawm BBP, ib hom yas yas, thiab nws muaj peev xwm ua rau lub cev xeeb tub.
Lwm cov kev tshawb fawb tseem tau hais txog qhov cuam tshuam tsis zoo ntawm plasticizers rau kev noj qab haus huv ntawm cov menyuam yaus. Piv txwv li, di(2-ethylhexyl) phthalate (DEHP) tau pom tias ua rau muaj kev puas tsuaj DNA ntau dhau thaum lub sij hawm ua me nyuam hauvC. elegans, cuam tshuam nrog kev kho lub cev thiab ua rau muaj qhov tsis xws luag hauv kev tsim oocyte thiab kev loj hlob ntawm embryonic thaum ntxov. DEHP yog ib qho ntawm cov khoom siv dav siv ntau tshaj plaws, nrog rau kev tsim khoom thoob ntiaj teb txhua xyoo txog li 4 lab tons. Tib neeg raug DEHP los ntawm ntau yam khoom, suav nrog cov khoom ua si, khaub ncaws, ntim khoom noj, khoom siv kho mob, thiab cov khoom tu tus kheej.
Kev phom sij ntawm Phthalates:
Toxicity rau txiv neej Reproductive System: Phthalates paub tias ua rau cov qog nqaij hlav toxicity, nrog rau cov qog nqaij hlav loj heev, kev hloov pauv tseem ceeb hauv qib testosterone, txo qis hauv cov spermatogenic hlwb, txo qis hauv cov qog nqaij hlav enzyme, thiab txo cov phev suav.
Toxicity rau poj niam Reproductive System: Phthalate esters muaj tshuaj lom rau ntawm lub tsev menyuam thiab zes qe menyuam, muaj peev xwm ua rau ncua sijhawm estrous cycles, txo cov qib progesterone, uterine hnyav nce, thiab hloov ovulation cycles, nrog rau ncua sij hawm los yog anovulatory cycles.
Cov teebmeem ntawm Ntshav Qab Zib: Kev cuam tshuam rau phthalates tuaj yeem ua rau txo qis hauv hematocrit, txo qis hemoglobin, thiab nce platelet adhesion.
Teratogenicity: Kev tshawb fawb qhia tias kev kis tus kab mob phthalates tsawg tuaj yeem ua rau muaj qhov tshwm sim ntawm tus menyuam hauv plab tuag. Kev kis mob hnyav kuj tseem tuaj yeem ua rau mob plawv, lub raum, thiab pulmonary toxicity, uas ua rau tuag taus.
Hepatic Toxicity: Phthalates tuaj yeem ua rau oxidative puas tsuaj rau cov protein, daim siab cell membranes, thiab DNA nyob rau hauv cov hlwb, muaj peev xwm txawm ua rau qia hlwb.
Carcinogenicity: Lub sij hawm ntev raug rau phthalates ua rau muaj kev pheej hmoo ntawm kev tsim cov kab mob malignant qia cell.
Peb lub tuam txhab muaj ntau yam phthalate-dawb, eco-friendly plasticizers (JDCH888 series, JDCH999 series) uas tsis muaj cov tshuaj phem xws li DEHP, BBP, DBP, lossis DIBP. Cov khoom no tau dhau SGS RoHS thiab lwm yam ntawv pov thawj. Yog xav paub ntxiv txog kev kuaj cov khoom, thov luam theej duab QR code hauv qab no.
